Article
Characterization of regulatory dendritic cells that mitigate acute graft-versus-host disease in older mice following allogeneic bone marrow transplantation.
PloS one - 1 Jan 2013
Scroggins Sabrina M, Olivier Alicia K, Meyerholz David K, Schlueter Annette J
Abstract excerpt
Despite improvements in human leukocyte antigen matching and pharmacologic prophylaxis, acute graft-versus-host disease (GVHD) is often a fatal complication following hematopoietic stem cell transplant (HSCT). Older HSCT recipients experience significantly increased morbidity and mortality compared to young recipients. Prophylaxis with syngeneic regulatory dendritic cells (DCreg) in young bone marrow transplanted...
Topics
- Acute Disease
- Adoptive Transfer
- Aging
- Animals
- B7-H1 Antigen
- Bone Marrow Transplantation
- Cytokines
- Dendritic Cells
- Gene Expression Regulation
- Graft vs Host Disease
- Humans
- Immune Tolerance
- Mice
- Phenotype