Article
Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.
Mucosal immunology - 1 Mar 2017
Fujimoto Kosuke, Kinoshita Makoto, Tanaka Hiroo, Okuzaki Daisuke, Shimada Yosuke, Kayama Hisako, Okumura Ryu, Furuta Yoki, Narazaki Masashi, Tamura Atsushi, Hatakeyama Shigetsugu, Ikawa Masahito, Tsuchiya Kiichiro, Watanabe Mamoru, Kumanogoh Atsushi, Tsukita Sachiko, Takeda Kiyoshi
Abstract excerpt
Genome-wide association studies and subsequent deep sequencing analysis have identified susceptible loci for inflammatory bowel diseases (IBDs) including ulcerative colitis (UC). A gene encoding RING finger protein 186 (RNF186) is located within UC-susceptible loci. However, it is unclear whether RNF186 is involved in IBD pathogenesis. Here, we show that RNF186 controls protein homeostasis in colonic epithelia...
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