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A Thiopurine-like Mutagenic Process Defines TGCT Subtypes

2025-06-12

Abstract excerpt

Testicular germ cell tumors (TGCTs) are the most common malignancy in young men, exhibit a unique developmental origin and exceptional chemosensitivity. However, the molecular distinctions between TGCT subtypes remain poorly understood. Here we present a comprehensive genomic analysis of 252 treatment-naive primary TGCTs, integrating deep whole-genome sequencing with matched transcriptomic and epigenomic data. We...

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Literature Corpus work
56d34e94-fb61-5c3a-bc4c-a937b45196db
DOI
10.1101/2025.06.12.655573
Open publication

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A Thiopurine-like Mutagenic Process Defines TGCT SubtypesDOI 10.1101/2025.06.12.655573
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