Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project.

doi:10.1038/s41467-024-53193-6

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Article

Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project.

Nature communications - 26 Oct 2024

Ní Leathlobhair Máire, Frangou Anna, Kinnersley Ben, Cornish Alex J, Chubb Daniel, Lakatos Eszter, Arumugam Prabhu, Gruber Andreas J, Law Philip, Tapinos Avraam, Jakobsdottir G Maria, Peneva Iliana, Sahli Atef, Smyth Evie M, Ball Richard Y, Sylva Rushan, Benes Ksenija, Stark Dan, Young Robin J, Lee Alexander T J, Wolverson Vincent, Houlston Richard S, Sosinsky Alona, Protheroe Andrew, Murray Matthew J, Wedge David C, Verrill Clare

Abstract excerpt

Testicular germ cell tumours (TGCT), which comprise seminoma and non-seminoma subtypes, are the most common cancers in young men. In this study, we present a comprehensive whole genome sequencing analysis of adult TGCTs. Leveraging samples from participants recruited via the UK National Health Service and data from the Genomics England 100,000 Genomes Project, our results provide an extended description of...

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Identifiers

PMID: 39461959
DOI: 10.1038/s41467-024-53193-6
PMCID: PMC11513037

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