Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling.

doi:10.1093/humrep/dex300

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Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling.

Human reproduction (Oxford, England) - 1 Dec 2017

Cools M, Wolffenbuttel K P, Hersmus R, Mendonca B B, Kaprová J, Drop S L S, Stoop H, Gillis A J M, Oosterhuis J W, Costa E M F, Domenice S, Nishi M Y, Wunsch L, Quigley C A, T'Sjoen G, Looijenga L H J

Abstract excerpt

STUDY QUESTION: What is the prevalence of malignant testicular germ cell tumors (TGCT) and its precursors, (pre-) germ cell neoplasia in situ (GCNIS), in late teenagers and adults who have androgen insensitivity syndrome (AIS) and the impact of an individual's genetic susceptibility to development of TGCT? SUMMARY ANSWER: No GCNIS or TGCT was diagnosed, but pre-GCNIS was identified in 14 and 10% of complete and...

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Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling.

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