Article
Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours.
Nature communications - 22 Jan 2015
Litchfield Kevin, Summersgill Brenda, Yost Shawn, Sultana Razvan, Labreche Karim, Dudakia Darshna, Renwick Anthony, Seal Sheila, Al-Saadi Reem, Broderick Peter, Turner Nicholas C, Houlston Richard S, Huddart Robert, Shipley Janet, Turnbull Clare
Abstract excerpt
Testicular germ cell tumours (TGCTs) are the most common cancer in young men. Here we perform whole-exome sequencing (WES) of 42 TGCTs to comprehensively study the cancer's mutational profile. The mutation rate is uniformly low in all of the tumours (mean 0.5 mutations per Mb) as compared with co...
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