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Article

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development.

Nature communications - 4 Jun 2020

Shankar Sunita, Tien Jean Ching-Yi, Siebenaler Ronald F, Chugh Seema, Dommeti Vijaya L, Zelenka-Wang Sylvia, Wang Xiao-Ming, Apel Ingrid J, Waninger Jessica, Eyunni Sanjana, Xu Alice, Mody Malay, Goodrum Andrew, Zhang Yuping, Tesmer John J, Mannan Rahul, Cao Xuhong, Vats Pankaj, Pitchiaya Sethuramasundaram, Ellison Stephanie J, Shi Jiaqi, Kumar-Sinha Chandan, Crawford Howard C, Chinnaiyan Arul M

Abstract excerpt

Both KRAS and EGFR are essential mediators of pancreatic cancer development and interact with Argonaute 2 (AGO2) to perturb its function. Here, in a mouse model of mutant KRAS-driven pancreatic cancer, loss of AGO2 allows precursor lesion (PanIN) formation yet prevents progression to pancreatic ductal adenocarcinoma (PDAC). Precursor lesions with AGO2 ablation undergo oncogene-induced senescence with altered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32499547
DOI: 10.1038/s41467-020-16309-2
PMCID: PMC7272436

Genes

AGO2
KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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