Article

Comprehensive Characterisation of Fetal and Mature Retinal Cell Identity to Assess the Fidelity of Retinal Organoids

2022-06-16

Abstract excerpt

<h4>Summary</h4> Characterizing cell identity in complex tissues such as the human retina is essential for studying its development and disease. While retinal organoids derived from pluripotent stem cells have been widely used to model development and disease of the human retina, there is a lack of studies that have systematically evaluated molecular and cellular fidelity of the organoids derived from various cul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c95da59b-1e37-515e-a45b-04a33c28c039
DOI: 10.1101/2022.06.13.495996

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Characterisation of Fetal and Mature Retinal Cell Identity to Assess the Fidelity of Retinal OrganoidsDOI 10.1101/2022.06.13.495996Read

Human retinal organoid single-cell atlas allows to reconstruct retinal development at high resolution and identify nature restricted transcriptional states in vitroSemantic proximity Read

Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease mapSemantic proximity Read

Identification and characterization of human retinal stem cells capable of retinal regenerationSemantic proximity Read

Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9- <i>cis</i> retinalSemantic proximity Read

Single-cell analysis reveals cellular heterogeneity and limits of marker-based assessment in retinal ganglion cell-enriched organoid culturesSemantic proximity Read

Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic useSemantic proximity Read

Retinal Organoids: A Human Model System for Development, Diseases, and Therapies.Semantic proximity Read

Comparison of Developmental Dynamics in Human Fetal Retina and Human Pluripotent Stem Cell-Derived Retinal TissueSemantic proximity Read

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.Semantic proximity Read

Multi-ocular Organoids from Human iPS Cells Displayed Retina, Cornea, and RPE LineagesSemantic proximity Read

Retinal organoids provide unique insights into molecular signatures of inherited retinal disease throughout retinogenesisSemantic proximity Read

Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cellsSemantic proximity Read