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Article

The impact of phenotypic- versus target-based approaches in antimalarial drug discovery in the last two decades (2005-2025).

Future medicinal chemistry - 1 Dec 2025

Cheuka Peter Mubanga, Mayoka Godfrey, Mambwe Dickson, Dawoodjee Ameera Mohammed, Zulu Ayanda

Abstract excerpt

INTRODUCTION: Malaria causes major mortality, with the downward trend in the number of cases and deaths seemingly stalled. In 2023, 95% of global malaria deaths were reported in the World Health Organization (WHO) African region, with children under the age of 5 years being the most affected. Artemisinin-combination therapies (ACTs), the currently recommended first-line treatments, are threatened by resistance,...

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Identifiers

PMID: 41178292
DOI: 10.1080/17568919.2025.2580928
PMCID: PMC12674392

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