Article

Defining the T cell transcriptional landscape in pediatric liver transplant rejection at single cell resolution

2024-02-29

Abstract excerpt

Acute cellular rejection (ACR) affects >80% of pediatric liver transplant recipients within 5 years, and late ACR is associated with graft failure. Traditional anti-rejection therapy for late ACR is ineffective and has remained unchanged for six decades. Although CD8+ T cells promote late ACR, little has been done to define their specificity and gene expression. Here, we used single-cell sequencing and immune repe...

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Literature Corpus work: 567aa542-1d1e-5ab8-8ab4-34898cb2b965
DOI: 10.1101/2024.02.26.582173

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