Article

Identification of Key Genes and Exploration of Immune Activation Pathways in T-cell Mediated Rejection through Integrated Bulk and Single-Cell RNA-Seq Analysis with Machine Learning

2024-07-15

Abstract excerpt

<title>Abstract</title> <p>Liver transplantation is the definitive treatment for end-stage liver disease, yet T-cell mediated rejection (TCMR) remains a major challenge. This study aims to identify key genes associated with TCMR and their potential biological processes and mechanisms. The GSE145780 dataset was subjected to differential expression analysis, weighted gene co-expression network analysis (WGCNA), and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 307f16e9-5506-54e2-8a0f-c56a3b5a975d
DOI: 10.21203/rs.3.rs-4583452/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of Key Genes and Exploration of Immune Activation Pathways in T-cell Mediated Rejection through Integrated Bulk and Single-Cell RNA-Seq Analysis with Machine LearningDOI 10.21203/rs.3.rs-4583452/v1Read

Key genes and immune pathways in T-cell mediated rejection post-liver transplantation identified via integrated RNA-seq and machine learningSemantic proximity Read

Landscape of the Immune Infiltration and Identification of Molecular Diagnostic Markers Associated With Immune Cells in Patients With Kidney TransplantationSemantic proximity Read

RNA-sequencing of Human Kidney Allografts and Delineation of T-Cell Genes, Gene Sets, and Pathways Associated With Acute T Cell–mediated RejectionSemantic proximity Read

A Unique Immune-Related Gene Signature Represents Advanced Liver Fibrosis and Reveals Potential Therapeutic TargetsSemantic proximity Read

Identification of distinct immune infiltration and potential biomarkers in patients with liver ischemia-reperfusion injurySemantic proximity Read

Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft RejectionSemantic proximity Read

Immune Cell Infiltration is Discriminative for ABMR and TCMRSemantic proximity Read

SLAMF8 Participates in Acute Renal Transplant Rejection via TLR4 Pathway on Pro-Inflammatory MacrophagesSemantic proximity Read

Noninvasive Identification of Core Gene Biomarkers in Patients with Acute Kidney Transplant RejectionSemantic proximity Read

Exploration of Signature Genes and Their Correlation with Immune Cell Infiltration in CirrhosisSemantic proximity Read

Single cell RNA-sequencing delineates CD8 + tissue resident memory T cells maintaining rejection in liver transplantationSemantic proximity Read