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Article

Tailored anesthesia protocols for echo-based HFpEF phenotyping in C57BL6/N mice.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2026

Wingert Julia, Haase Leonard, Meinhardt Eric, Frey Norbert, Schlegel Philipp

Abstract excerpt

Echocardiographic evaluation of diastolic function in murine heart failure with preserved ejection fraction (HFpEF) models remains challenging due to insufficient temporal resolution of current high-frequency Doppler probes at heart rates beyond 450 beats/min. Aiming to optimize anesthesia for diastolic assessment in mice, we compared standard isoflurane sedation with a combination of isoflurane and either of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42370963
DOI: 10.1152/ajpheart.00319.2026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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