Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

Molecular cell - 7 May 2015

Thomas Lance R, Wang Qingguo, Grieb Brian C, Phan Jason, Foshage Audra M, Sun Qi, Olejniczak Edward T, Clark Travis, Dey Soumyadeep, Lorey Shelly, Alicie Bethany, Howard Gregory C, Cawthon Bryan, Ess Kevin C, Eischen Christine M, Zhao Zhongming, Fesik Stephen W, Tansey William P

Abstract excerpt

MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. The oncogenic potential of MYC stems from its ability to bind regulatory sequences in thousands of target genes, which depends on interaction of MYC with its obligate partner, MAX. Here, we show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anisotropy
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Fluorescence Polarization

Share to Mice, Nude

Share to NIH 3T3 Cells

Share to Proto-Oncogene Proteins c-myc

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 25818646
DOI: 10.1016/j.molcel.2015.02.028
PMCID: PMC4427524

Genes

MYC
MAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25818646-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.PMID 25818646Read ↗

Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC InteractionSemantic proximity Read ↗

Probing the Cancer Mutational Landscape of KMT2 Regulatory Subunits.Semantic proximity Read ↗

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in NeuroblastomaSemantic proximity Read ↗

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastomaSemantic proximity Read ↗

Pharmacologic degradation of WDR5 suppresses oncogenic activities of SS18::SSX and provides a therapeutic of synovial sarcomaSemantic proximity Read ↗

PRMT5 as an Epigenetic Target for Group 3 (MYC-driven) MedulloblastomaSemantic proximity Read ↗

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse modelsSemantic proximity Read ↗

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic CancerSemantic proximity Read ↗

MYCbase: a database of functional sites and biochemical properties of Myc in both normal and cancer cells.Semantic proximity Read ↗

MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and AgingSemantic proximity Read ↗

Targeting WDR5/ATAD2 signaling by the CK2/IKAROS axis demonstrates therapeutic efficacy in T-ALLSemantic proximity Read ↗

E26 transformation-specific transcription variant 5 in development and cancer: modification, regulation and functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.