Article

Coevolutionary landscape inference and the context-dependence of mutations in beta-lactamase TEM-1

2015-10-13

Abstract excerpt

The quantitative characterization of mutational landscapes is a task of outstanding importance in evolutionary and medical biology: It is, e.g., of central importance for our understanding of the phenotypic effect of mutations related to disease and antibiotic drug resistance. Here we develop a novel inference scheme for mutational landscapes, which is based on the statistical analysis of large alignments of homol...

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Literature Corpus work: 565ba967-f644-554e-a2c4-0a6a3b7b11ed
DOI: 10.1101/028902

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