Article

Network mechanisms in rapid-onset dystonia-parkinsonism

2024-10-16

Abstract excerpt

<h4>Background</h4> Rapid-onset dystonia-parkinsonism (RDP) is a rare neurological disorder caused by mutations in the ATP1A3 gene. Symptoms are characterized by a dystonia-parkinsonism. Recently, experimental studies have shown that the pathophysiology of the disease is based on a combined dysfunction of the cerebellum (CB) and basal ganglia (BG) and that blocking their interaction can alleviate the symptoms. Th...

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Literature Corpus work: f61fc5d2-60fe-56ec-ab0e-2528ba3bb543
DOI: 10.1101/2024.10.14.618133

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