Article

Patient-specific multi-modal modeling uncovers neurotransmitter receptor involvement in motor and non-motor axes of Parkinson’s disease

2023-03-22

Abstract excerpt

Multi-systemic neurodegeneration in Parkinson’s disease (PD) is increasingly acknowledged, involving several neurotransmitter systems beyond the classical dopaminergic circuit and resulting in heterogeneous motor and non-motor symptoms. Nevertheless, the mechanistic basis of neuropathological and symptomatic heterogeneity remains unclear. Here, we use patient-specific generative brain modeling to identify neurotra...

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Literature Corpus work: 0ae8e1bd-681b-5c5f-8ba4-59e53735169d
DOI: 10.1101/2023.03.22.23287578

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