Article
Methylomics of gene expression in human monocytes.
Human molecular genetics - 15 Dec 2013
Liu Yongmei, Ding Jingzhong, Reynolds Lindsay M, Lohman Kurt, Register Thomas C, De La Fuente Alberto, Howard Timothy D, Hawkins Greg A, Cui Wei, Morris Jessica, Smith Shelly G, Barr R Graham, Kaufman Joel D, Burke Gregory L, Post Wendy, Shea Steven, McCall Charles E, Siscovick David, Jacobs David R, Tracy Russell P, Herrington David M, Hoeschele Ina
Abstract excerpt
DNA methylation is one of several epigenetic mechanisms that contribute to the regulation of gene expression; however, the extent to which methylation of CpG dinucleotides correlates with gene expression at the genome-wide level is still largely unknown. Using purified primary monocytes from subjects in a large community-based cohort (n = 1264), we characterized methylation (>485 000 CpG sites) and mRNA...
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