Article
Detection of ALK rearrangement by immunohistochemistry in lung adenocarcinoma and the identification of a novel EML4-ALK variant.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2013
To Ka-Fai, Tong Joanna H M, Yeung King S F, Lung Raymond W M, Law Peggy P Y, Chau Shuk Ling, Kang Wei, Tong Carol Y K, Chow Chit, Chan Anthony W H, Leung Linda K S, Mok Tony S K
Abstract excerpt
INTRODUCTION: The echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) fusion gene has been identified as a potent oncogenic driver in non-small-cell lung cancer, in particular adenocarcinoma (ADC). It defines a unique subgroup of lung ADC, which may be responsive to ALK inhibitors. Detection of ALK rearrangement by fluorescence in situ hybridization (FISH) or reverse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.