Article

Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer

2024-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Molecular subtypes of Small Cell Lung Cancer (SCLC) have been described based on differential expression of transcription factors (TFs) ASCL1, NEUROD1 , POU2F3 and immune-related genes. We previously reported an additional subtype based on expression of the neurogenic TF ATOH1 within our SCLC Circulating tumour cell- Derived eXplant (CDX) model biobank. Here we show that ATOH1 protein was det...

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Literature Corpus work: 56407eea-16ad-5878-89e1-bce628725187
DOI: 10.1101/2024.02.16.580247

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