Article
KRAS Mutation and Consensus Molecular Subtypes 2 and 3 Are Independently Associated with Reduced Immune Infiltration and Reactivity in Colorectal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2018
Lal Neeraj, White Brian S, Goussous Ghaleb, Pickles Oliver, Mason Mike J, Beggs Andrew D, Taniere Philippe, Willcox Benjamin E, Guinney Justin, Middleton Gary W
Abstract excerpt
Purpose:KRAS mutation is a common canonical mutation in colorectal cancer, found at differing frequencies in all consensus molecular subtypes (CMS). The independent immunobiological impacts of RAS mutation and CMS are unknown. Thus, we explored the immunobiological effects of KRAS mutation across the CMS spectrum.Experimental Design: Expression analysis of immune genes/signatures was performed using The Cancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.