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Article

Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients.

Journal of translational medicine - 7 Jan 2021

Liu Jungang, Huang Xiaoliang, Liu Haizhou, Wei Chunyin, Ru Haiming, Qin Haiquan, Lai Hao, Meng Yongsheng, Wu Guo, Xie Weishun, Mo Xianwei, Johnson Caroline H, Zhang Yawei, Tang Weizhong

Abstract excerpt

BACKGROUND: KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). KRAS mutation-mediated regulation of immunophenotype and immune pathways in CRC remains to be elucidated. METHODS: 535 CRC patients were used to compare the expression of immune-related genes (IRGs) and the abundance of tumor-infiltrating immune cells (TIICs) in the tumor microenvironment between KRAS-mutant and KRAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33413474
DOI: 10.1186/s12967-020-02638-9
PMCID: PMC7789428

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