Article

SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancer

2025-07-19

Abstract excerpt

<h4>Summary</h4> Treatment options and diagnostic outlook for men with advanced, therapy resistant prostate cancer (PCa) are extremely poor; this is primarily due to the common lack of durable response to androgen receptor (AR) targeted therapies and phenotypic transdifferentiation into a particularly lethal subtype known as neuroendocrine prostate cancer (NEPC). In this study, we mechanistically determine that S...

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Literature Corpus work: 5611efe8-a91a-564a-abb4-088b70963769
DOI: 10.1101/2025.07.18.664790

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