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Article

Sox2 Is an Androgen Receptor-Repressed Gene That Promotes Castration-Resistant Prostate Cancer

11 Jan 2013

Abstract excerpt

Despite advances in detection and therapy, castration-resistant prostate cancer continues to be a major clinical problem. The aberrant activity of stem cell pathways, and their regulation by the Androgen Receptor (AR), has the potential to provide insight into novel mechanisms and pathways to prevent and treat advanced, castrate-resistant prostate cancers. To this end, we investigated the role of the embryonic...

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Identifiers

PMID: 23326489
DOI: 10.1371/journal.pone.0053701

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sox2 Is an Androgen Receptor-Repressed Gene That Promotes Castration-Resistant Prostate CancerPMID 23326489Read ↗

SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancerSemantic proximity Read ↗

SOX2 expression in prostate cancer drives resistance to nuclear hormone receptor signaling inhibition through the WEE1/CDK1 signaling axisSemantic proximity Read ↗

Sox2 Expression Marks Castration-Resistant Progenitor Cells in the Adult Murine ProstateSemantic proximity Read ↗

Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like CharacteristicsSemantic proximity Read ↗

Overexpression of SOX2 Gene by Histone Modifications: SOX2 Enhances Human Prostate and Breast Cancer Progression by Prevention of Apoptosis and Enhancing Cell ProliferationSemantic proximity Read ↗

SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cellSemantic proximity Read ↗

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancerSemantic proximity Read ↗

SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cellsSemantic proximity Read ↗

AR suppression rewires a SOX4 regulatory program to promote enzalutamide resistance in prostate cancerSemantic proximity Read ↗

Cancer-driven IgG promotes the development of castration-resistant Prostate Cancer though the SOX2-CIgG pathwaySemantic proximity Read ↗

The SOX4/miR-17-92/RB1 Axis Promotes Prostate Cancer ProgressionSemantic proximity Read ↗

Sex-Determining Region Y Box 4 Is a Transforming Oncogene in Human Prostate Cancer CellsSemantic proximity Read ↗

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