Article

Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

2022-11-12

Abstract excerpt

Outer arm dynein (OAD) is the main force generator of ciliary beating. Although OAD loss is the most frequent cause of human primary ciliary dyskinesia, the docking mechanism of OAD onto the ciliary doublet microtubule (DMT) remains elusive in vertebrates. Here, we analyzed the functions of Calaxin/Efcab1 and Armc4, the components of vertebrate OAD-DC (docking complex), using zebrafish spermatozoa and cryo-electro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56043646-169b-568b-ac38-ee099dec63fc
DOI: 10.1101/2022.11.10.516068

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebratesDOI 10.1101/2022.11.10.516068Read

Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates.Semantic proximity Read

Pathogenic variants in CLXN encoding the outer dynein arm docking-associated calcium-binding protein calaxin cause primary ciliary dyskinesia.Semantic proximity Read

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EMSemantic proximity Read

TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization.Semantic proximity Read

Cytoplasmic dynein-2 at a glanceSemantic proximity Read

Detailed structural and biochemical characterization of the nexin-dynein regulatory complex.Semantic proximity Read

The connecting cilium inner scaffold provides a structural foundation to maintain photoreceptor integritySemantic proximity Read

CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation.Semantic proximity Read

De novo identification of mammalian ciliary motility proteins using cryo-EM.Semantic proximity Read

ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.Semantic proximity Read

In-cell structural insight into the asymmetric assembly of central apparatus in mammalian sperm axonemeSemantic proximity Read

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and AppendagesSemantic proximity Read