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Article

Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates.

eLife - 14 Apr 2023

Yamaguchi Hiroshi, Morikawa Motohiro, Kikkawa Masahide

Abstract excerpt

Outer arm dynein (OAD) is the main force generator of ciliary beating. Although OAD loss is the most frequent cause of human primary ciliary dyskinesia, the docking mechanism of OAD onto the ciliary doublet microtubule (DMT) remains elusive in vertebrates. Here, we analyzed the functions of Calaxin/Efcab1 and Armc4, the two of five components of vertebrate OAD-DC (docking complex), using zebrafish spermatozoa and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37057896
DOI: 10.7554/eLife.84860
PMCID: PMC10139691

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