Biomechanical 3D tumor models on a micro-milled high-throughput force sensor array

Abstract excerpt

<h4>ABSTRACT</h4> The tumor microenvironment plays a critical role in drug resistance, with extracellular matrix (ECM) mechanics, cell-cell crosstalk, and transport barriers contributing to poor therapeutic outcomes. Traditional two-dimensional (2D) cultures fail to capture these features, and drug efficacy in 2D often does not translate to three-dimensional (3D) models or in vivo tumors. Here, we introduce a 3D...

Topics

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• 3D Printing in Biomedical Research
• Cancer Cells and Metastasis
• Cell Image Analysis Techniques
• Cellular Mechanics and Interactions
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

fd7df54d-18f2-56d9-9fa1-5bc46a763c7b

DOI

10.1101/2025.09.22.677940