Article

Divergent effects of a Treg-selective IL-2 mutein on Influenza specific T cell responses

2025-06-16

Abstract excerpt

Enhancing regulatory T cell (Treg) function offers a compelling therapeutic strategy for autoimmune disease. Engineered IL-2 muteins selectively expand functional Tregs with minimal impact on other immune cells, but their potential to compromise antiviral immunity remains largely unexplored. Here, we used a murine model of Influenza A virus (Flu) infection to determine how IL-2 mutein shapes T cell responses to re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9afa8c0c-0c97-5f0a-b67b-42ee1ea47fb2
DOI: 10.1101/2025.06.10.658962

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Divergent effects of a Treg-selective IL-2 mutein on Influenza specific T cell responsesDOI 10.1101/2025.06.10.658962Read

Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunitySemantic proximity Read

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice.Semantic proximity Read

An IL-2 mutein increases IL-10 and CTLA-4-dependent suppression of dendritic cells by regulatory T cellsSemantic proximity Read

In Vivo Expansion of Antigen-Specific Regulatory T Cells through Staggered Fc.IL-2 Mutein Dosing and Antigen-Specific Immunotherapy.Semantic proximity Read

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T cell responses during chronic viral infectionSemantic proximity Read

Influenza infection recruits distinct waves of regulatory T cells to the lung that limit lung resident IgA+ B cellsSemantic proximity Read

Synergistic activity of IL-2 mutein with tolerogenic ImmTOR nanoparticles leads to massive expansion of antigen-specific Tregs and protection against autoimmune diseaseSemantic proximity Read

Re-shaping the immune response to influenza vaccination in a host with immune memory from influenzaSemantic proximity Read

Selective impact on regulatory T cells with sustained functional phenotypes by the interleukin-2 mutein VIS171 in a nonhuman primate model.Semantic proximity Read

The antitumor effect induced by an IL-2 'no-alpha' mutein depends on changes in the CD8+ T lymphocyte/Treg cell balance.Semantic proximity Read

Differentiating PD-1+ stem-like CD8 T cells towards distinct effectors with enhanced therapeutic potential by an engineered IL-2 cis-targeted to PD-1Semantic proximity Read

KLF2 inhibition expands tumor-resident T cells and enhances tumor immunitySemantic proximity Read