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A PBD-dimer containing antibody drug conjugate targeting CCRL2 for high-risk MDS/AML

2025-10-29

Abstract excerpt

<title>Abstract</title> <p> Patients with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) with high-risk features including <italic>TP53</italic> mutations have poor outcomes due to lack of effective therapies. The atypical chemokine surface receptor C-C motif chemokine receptor-like 2 (CCRL2) is overexpressed in MDS and secondary AML (sAML) compared to healthy hematopoietic cells and we recently f...

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Literature Corpus work
dc195dd9-c827-588d-a591-60326c64b840
DOI
10.21203/rs.3.rs-7763372/v1
Open publication

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