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Article

Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells

20 Jan 2021

Abstract excerpt

Precise replacement of diseased or dysfunctional organs is the goal of regenerative medicine and has appeared to be a distant goal for a long time. In the field of hematopoietic stem cell transplantation, this goal is now becoming tangible as gene-editing technologies and novel conditioning agents are entering the clinical arena. Targeted immunologic depletion of hematopoietic stem cells (HSCs), which are at the...

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PMID: 33484750
DOI: 10.1016/j.exphem.2021.01.003

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