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Integrating Machine Learning and Single-Cell Sequencing: Decoding Histone Deacetylase Genes-Based Diagnostic Features and Immune Cell Dynamics in Ischemic Stroke

2025-10-15

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<title>Abstract</title> <p>Ischemic stroke (IS) involves dysregulated histone deacetylase (HDAC)-mediated epigenetic pathways, a mechanism often implicated in microglial activity during stroke. However, the clinical relevance and transcriptional mechanisms of HDACs in human IS remain unclear. Using GEO datasets (GSE22255 and GSE58294), we analyzed HDAC expression and identified significant downregulation of HDAC2...

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Literature Corpus work
a26497f9-d259-5366-a920-62063359ca47
DOI
10.21203/rs.3.rs-7586916/v1
Open publication

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