Article

Immune Checkpoint B7-H3 Inhibition Reprograms Acute Neuroinflammation and Protects the Brain After Acute Ischemic Stroke

2026-02-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND AND PURPOSE</h4> The role of immune checkpoint B7-H3 in acute ischemic stroke prognosis and post-stroke immunosuppression remains uninvestigated, despite the clinical significance of immune checkpoints with inflammaging and post-stroke infections. We recently reported the neuroprotective effects of acute B7-H3 inhibition after stroke in adult and aged mice. In this study, we inve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3525ebd2-7df1-5fb5-8582-2dfdd09584eb
DOI: 10.64898/2026.02.26.708106

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune Checkpoint B7-H3 Inhibition Reprograms Acute Neuroinflammation and Protects the Brain After Acute Ischemic StrokeDOI 10.64898/2026.02.26.708106Read

Molecular and anatomical roadmap of stroke pathology in immunodeficient miceSemantic proximity Read

Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humansSemantic proximity Read

Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemiaSemantic proximity Read

The Two Faces of HDAC3: Neuroinflammation in Disease and Neuroprotection in RecoverySemantic proximity Read

Gut microbiota mediates trafficking of intestinal T cells to the brain to exacerbate neuroinflammation after ischemic strokeSemantic proximity Read

Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer’s diseaseSemantic proximity Read

Decoding the transcriptional response to ischemic stroke in young and aged mouse brainSemantic proximity Read

Innate immune memory after brain injury drives inflammatory cardiac dysfunctionSemantic proximity Read

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and edema in intracerebral hemorrhageSemantic proximity Read

Novel Therapeutic Strategy Targeting Hspa8 for Ischemic Brain InjurySemantic proximity Read

Histone deacetylase 3 regulates microglial function through histone deacetylationSemantic proximity Read

GSK-126 protects CA1 neurons from H3K27me3-mediated apoptosis in cerebral ischemiaSemantic proximity Read