Article

Quantitative in vitro to in vivo Extrapolation (IVIVE) of Genotoxicity Data Provides Protective Estimates of in vivo Dose

2022-11-21

Abstract excerpt

Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, aneugenicity) have been limited to dichotomous hazard classification, while other toxicity endpoints are assessed through quantitative determination of points-of-departure (PODs) for setting exposure limits. The more recent higher-throughput in vitro g...

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Literature Corpus work: 55a58c6c-1c0b-5fd6-bfc4-6f81230c02a8
DOI: 10.22541/au.166906427.70641401/v1

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