Article
Quantitative approaches for assessing dose-response relationships in genetic toxicology studies.
Environmental and molecular mutagenesis - 1 Jan 2013
Gollapudi B B, Johnson G E, Hernandez L G, Pottenger L H, Dearfield K L, Jeffrey A M, Julien E, Kim J H, Lovell D P, Macgregor J T, Moore M M, van Benthem J, White P A, Zeiger E, Thybaud V
Abstract excerpt
Genetic toxicology studies are required for the safety assessment of chemicals. Data from these studies have historically been interpreted in a qualitative, dichotomous "yes" or "no" manner without analysis of dose-response relationships. This article is based upon the work of an international multi-sector group that examined how quantitative dose-response relationships for in vitro and in vivo genetic toxicology...
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