Article
Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose.
Environmental and molecular mutagenesis - 1 Feb 2023
Beal Marc A, Audebert Marc, Barton-Maclaren Tara, Battaion Hannah, Bemis Jeffrey C, Cao Xuefei, Chen Connie, Dertinger Stephen D, Froetschl Roland, Guo Xiaoqing, Johnson George, Hendriks Giel, Khoury Laure, Long Alexandra S, Pfuhler Stefan, Settivari Raja S, Wickramasuriya Shamika, White Paul
Abstract excerpt
Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, and aneugenicity) have been limited to dichotomous hazard classification, while other toxicity endpoints are assessed through quantitative determination of points-of-departures (PODs) for setting exposure limits. The more recent higher-throughput in...
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