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Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

1 Jun 2014

Abstract excerpt

Genetically engineered human pluripotent stem cells (hPSCs) have been proposed as a source for transplantation therapies and are rapidly becoming valuable tools for human disease modeling. However, many applications are limited due to the lack of robust differentiation paradigms that allow for the isolation of defined functional tissues. Here, using an endogenous LGR5-GFP reporter, we derived adult stem cells...

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PMID: 24936470
DOI: 10.1016/j.stemcr.2014.05.001

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