Article

Structure of the lysosomal membrane fusion machinery

2022-05-05

Abstract excerpt

Lysosomes are of central importance in cellular recycling, nutrient signaling 1,2 and endocytosis, and are tightly connected to autophagy 3 and the invasion of pathogenic bacteria and viruses 1,4 . Lysosomal fusion events are fundamental to cell survival and require HOPS, a conserved heterohexameric tethering complex 5,6 . HOPS recognizes and binds small membrane-associated GTPases on lysosomes and organelles,...

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Literature Corpus work: 556a9d1c-5733-5bae-bbb1-b180fe774088
DOI: 10.1101/2022.05.05.490745

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