Article
Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes.
Proceedings of the National Academy of Sciences of the United States of America - 8 Mar 2011
Bian Xin, Klemm Robin W, Liu Tina Y, Zhang Miao, Sun Sha, Sui Xuewu, Liu Xinqi, Rapoport Tom A, Hu Junjie
Abstract excerpt
The generation of the tubular network of the endoplasmic reticulum (ER) requires homotypic membrane fusion that is mediated by the dynamin-like, membrane-bound GTPase atlastin (ATL). Here, we have determined crystal structures of the cytosolic segment of human ATL1, which give insight into the mechanism of membrane fusion. The structures reveal a GTPase domain and athree-helix bundle, connected by a linker...
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