Article

Towards understanding cancer stem cell heterogeneity in the tumor microenvironment

2018-09-05

Abstract excerpt

The Epithelial-Mesenchymal Transition (EMT) and Cancer Stem Cell (CSC) formation are two paramount processes driving tumor progression, therapy resistance and cancer metastasis. Some recent experiments show that cells with varying EMT and CSC phenotypes are spatially segregated in the primary tumor. The underlying mechanisms generating such spatiotemporal dynamics and heterogeneity in the tumor micro-environment,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55604203-dc00-5d7c-b972-f6ee2257018d
DOI: 10.1101/408823

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Towards understanding cancer stem cell heterogeneity in the tumor microenvironmentDOI 10.1101/408823Read

Toward understanding cancer stem cell heterogeneity in the tumor microenvironmentSemantic proximity Read

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signalingSemantic proximity Read

Quantifying Cancer Epithelial-Mesenchymal Plasticity and Its Association with Stemness and Immune ResponseSemantic proximity Read

Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune ResponseSemantic proximity Read

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signalingSemantic proximity Read

Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network TopologySemantic proximity Read

Hybrid E/M phenotype(s) and stemness: a mechanistic connection embedded in network topologySemantic proximity Read

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic TargetsSemantic proximity Read

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor SurvivalSemantic proximity Read

Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype.Semantic proximity Read

Interconnected high-dimensional landscapes of epithelial–mesenchymal plasticity and stemness in cancerSemantic proximity Read

Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneitySemantic proximity Read