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Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response

22 May 2019

Abstract excerpt

Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer cells play a pivotal role in seeding metastases and their presence in cancer patients indicates...

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PMID: 31121840
DOI: 10.3390/jcm8050725

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