Article
Autoantibodies against nephrin elucidate a novel autoimmune phenomenon in proteinuric kidney disease
2021-03-02
Abstract excerpt
Dysfunction of podocytes, cells critical for glomerular filtration, underlies proteinuria and kidney failure. Genetic forms of proteinuric kidney disease can be caused by mutations in several podocyte genes, including nephrin, a critical component of the kidney filter. In contrast, the etiology of acquired acute-onset nephrotic syndrome has remained elusive. Here we identify autoantibodies against nephrin in serum...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 55572dc8-e770-575e-8318-63885563319f
- DOI
- 10.1101/2021.02.26.21251569