Autoantibodies Targeting Proteasome Subunit Alpha Type 1 in Autoimmune Podocytopathies

Abstract excerpt

Key Points Serum anti-proteasome subunit alpha type 1 (PSMA1) autoantibodies were specifically elevated in the active phase of idiopathic nephrotic syndrome, which may assist in disease diagnosis and monitoring. Serum anti-PSMA1 antibodies could cause damage to the glomerular filtration barrier, which may be a pathogenic antibody of idiopathic nephrotic syndrome. PSMA1 played an important role in the maintenance...

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