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Potential and pitfalls of measuring circulating anti-nephrin autoantibodies in glomerular diseases

11 Apr 2025

Abstract excerpt

Recent studies have identified autoantibodies targeting the podocyte protein nephrin in patients with primary podocytopathies such as minimal change disease, primary focal segmental glomerulosclerosis (FSGS), post-transplant recurrent FSGS and childhood idiopathic nephrotic syndrome. These antibodies bind nephrin and directly influence nephrin downstream signaling, with immense effect on the podocytes' cellular...

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PMID: 40342623
DOI: 10.1093/ckj/sfaf100

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