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Perspectives in membranous nephropathy

6 Apr 2021

Abstract excerpt

The identification of the phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing protein 7A (THSD7A) as podocyte antigens in adult patients with membranous nephropathy (MN) has strongly impacted both experimental and clinical research on this disease. Evidence has been furnished that podocyte-directed autoantibodies can cause MN, and novel PLA2R- and THSD7A-specific animal models have...

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PMID: 33825066
DOI: 10.1007/s00441-021-03429-4

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