Article

Differential Effects of Prostaglandin E <sub>2</sub> Production and Signaling through the Prostaglandin EP3 Receptor on Human Beta-cell Compensation

2019-06-13

Abstract excerpt

<h4>Objective</h4> Signaling through Prostaglandin E3 Receptor (EP3), a G protein-coupled receptor for E series prostaglandins such as prostaglandin E 2 (PGE 2 ), has been linked to the beta-cell dysfunction and loss of beta-cell mass in type 2 diabetes (T2D). In the beta-cell, EP3 is specifically coupled to the unique cAMP-inhibitory G protein, G z . Divergent effects of EP3 agonists and antagonists or Gα z...

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Literature Corpus work: 30a949be-5e7a-5a09-be54-0a49c7debd1d
DOI: 10.1101/670000

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