Article

Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes

2021-12-07

Abstract excerpt

<h4>ABSTRACT</h4> Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors can generate β-like gut cells. Pan-intestinal epithelial FoxO1 ablation expanded the EEC pool, induced β-like cells, and improved glucose tolerance in Ins2 Ak...

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Literature Corpus work: 8398dfa5-9ee5-57ff-a633-654f8287febd
DOI: 10.1101/2021.12.07.471572

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