Sex differences distinguish performance in four object recognition-based memory tasks in the Pink1-/- rat model of Parkinson’s disease

Abstract excerpt

<h4>ABSTRACT</h4> Many patients with Parkinson’s disease (PD) experience early, sometimes prodromal non-motor deficits involving cognition and memory. These so-called mild cognitive impairments hold dire predictions for future risk of freezing, falls and developing PD-related dementia. Moreover, due to a dearth of effective treatments, these symptoms persist and progressively worsen. Thus, there is an urgent need...

Topics

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• Animals, Genetically Modified
• Circadian Rhythm
• Learning Disabilities
• Locomotion
• Maze Learning
• Membrane Potentials
• Odorants
• Patch-Clamp Techniques

Identifiers and source

Literature Corpus work

55431600-682f-5262-bae0-d662a54e3e2f

DOI

10.1101/2025.02.19.639089