Article

Characterization of Nonmotor Symptoms in the MitoPark Mouse Model of Parkinson’s Disease

2020-11-03

Abstract excerpt

Mitochondrial dysfunction has been implicated as a key player in the pathogenesis of Parkinson’s disease (PD). The MitoPark mouse, a transgenic mitochondrial impairment model developed by specific inactivation of TFAM in dopaminergic neurons, spontaneously exhibits progressive motor deficits and neurodegeneration, recapitulating several features of PD. Since non-motor symptoms are now recognized as important featu...

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Literature Corpus work: 52a3cfcf-024e-58f5-90dd-d54f18b36247
DOI: 10.1101/2020.11.02.365874

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