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Article

Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease.

PloS one - 1 Jan 2014

Rial Daniel, Castro Adalberto A, Machado Nuno, Garção Pedro, Gonçalves Francisco Q, Silva Henrique B, Tomé Angelo R, Köfalvi Attila, Corti Olga, Raisman-Vozari Rita, Cunha Rodrigo A, Prediger Rui D

Abstract excerpt

There is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits are recognized as early non-motor manifestations of PD, and are not attenuated by the current anti-parkinsonian therapy. Although loss-of-function mutations in the...

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PMID: 25486126
DOI: 10.1371/journal.pone.0114216
PMCID: PMC4259468

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