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Article

Behavioral Phenotyping in a Murine Model of GBA1-Associated Parkinson Disease.

International journal of molecular sciences - 25 Jun 2021

Do Jenny, Perez Gani, Berhe Bahafta, Tayebi Nahid, Sidransky Ellen

Abstract excerpt

Mutations in GBA1, the gene encoding glucocerebrosidase, are common genetic risk factors for Parkinson disease (PD). While the mechanism underlying this relationship is unclear, patients with GBA1-associated PD often have an earlier onset and faster progression than idiopathic PD. Previously, we modeled GBA1-associated PD by crossing gba haploinsufficient mice with mice overexpressing a human mutant α-synuclein...

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Identifiers

PMID: 34202076
DOI: 10.3390/ijms22136826
PMCID: PMC8267726

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