Article

Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesis

2021-09-10

Abstract excerpt

Vesicle trafficking and the establishment of apico-basal polarity are essential processes in epithelium morphogenesis. Myosin-1b, an actin-motor able to bind membranes, regulates membrane shaping and vesicle trafficking. Here, we investigate Myosin-1b function in gut morphogenesis and congenital disorders using cell line and zebrafish larvae as well as patient biopsies. In a 3D Caco-2 cyst model, lumen formation i...

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Literature Corpus work: 55277b1a-6d22-57a4-ad2d-019987c60c9a
DOI: 10.1101/2021.09.09.459609

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